She has distinguished herself in numerous roles in the leading international opera houses, including Cleopatra (Giulio Cesare) and Morgana (Alcina) at the Opéra de Paris, Dalinda (Ariodante) at the Salzburg Festival, Alcina, Mélisande, Sandrina (La Finta Giardiniera), Sister Constance (Dialogues des Carmélites) at La Monnaie, Alcina and Dalinda in Amsterdam, Pamina (Die Zauberflöte), Donna Anna (Don Giovanni) and Sister Constance at the Théâtre des Champs-Élysées, and Despina (Così fan tutte) and Tytania (A Midsummer Night’s Dream) at the Festival d’Aix-en-Provence.

Sandrine Piau appears regularly in concerts with orchestra and as a recitalist, notably in New York, Paris, London, Tokyo, Munich, Zurich and Salzburg.

She previously made four solo discs of Handel and Mozart arias and recorded two recital programmes, Après un Rêve and Évocations, attesting her close partnership with Susan Manoff, with whom she appears regularly on the concert platform (Carnegie Hall, Wigmore Hall, tours of the United States and Japan). The operatic recital Desperate Heroines, with the Mozarteumorchester Salzburg under Ivor Bolton, received unanimous critical acclaim. Sandrine Piau now records exclusively for Alpha Classics. Her first disc on the label was a recital programme with Susan Manoff entitled Chimère. Her recital Si j’ai aimé, with Le Voncert de la Loge under the direction of Julien Chauvin, received a Diapason d’Or, a Choc de Classica and a Gramophone Award. In 2019 Alpha released Pergolesi’s Stabat Mater with Les Talens Lyriques directed by Christophe Rousset.

The 2019/20 season saw her take part in a major tour to celebrate the fortieth anniversary of Les Arts Florissants, a European tour with Teodor Currentzis, and concert performances of Debussy’s Le Martyre de saint Sébastien conducted by Valery Gergiev.

Among her projects for the 2020/21 season are concert tours of Europe with a number of ensembles including Kammerorchester Basel and Il Giardino Armonico, and the premiere of Kaija Saariaho’s Innocence at Aix-en-Provence.

Sandrine Piau was appointed Chevalier de l'Ordre des Arts et des Lettres in 2006 and voted Vocal Artist of the Year at the Victoires de la Musique Classique 2009.