Ensemble Profeti della Quinta was founded in the Galilee region of Israel by the bass singer and harpsichordist Elam Rotem, and is based in Basel, Switzerland, where its members undertook further studies of early music at the Schola Cantorum Basiliensis. The ensemble collaborates regularly with colleagues from Switzerland, Japan and Australia, sharing with them similar musical ideas.

Profeti della Quinta have been active in performing and researching hitherto neglected repertoire, such as Emilio de' Cavalieri's Lamentations (1600) and Salomone Rossi's Hashirim asher li'Shlomo (1623), the first publication of polyphony in Hebrew, which they also recorded to critical acclaim. In July 2011 the ensemble won the York Early music young artists competition, and ever since it performs regularly in prestigious music festivals and venues such as the Oude Muziek Festival Utrecht (the Netherlands), St. Michel en Thierarche baroque music Festival (France), Musikfestpiele Potsdam (Germany) and many more. Highlights of 2014 include debuts in the USA and in Japan, as well as concerts in Canada, Switzerland, Germany, Austria, France and the Netherlands.

The ensemble has recorded a number of CDs for PAN Classics and Linn Records, including music by Salomone Rossi as well as compositions by Elam Rotem. In 2012 Profeti della Quinta took part in a documentary film about Salomone Rossi, flimed in his hometown of Mantua. Numerous concerts by the ensemble were broadcast live or recorded by classical radio channels such as BBC Radio 3 (United Kingdom), France Musique, Switzerland DRS2, Israel's Voice of Music and many more.